November 30, 2022

CDC releases new clinical details in cases of unusual hepatitis in children

2 min read


So far, at least 18 cases have been reported in at least four states – and dozens more in Europe.

The latest medical details shared by the CDC on Friday came from Alabama, where the first cases were found. The clinical records of a total of nine patients admitted to the Children’s Hospital after October 1, 2021 were analyzed.

The patients were from different parts of the state and had nothing to do with epidemics. All were generally considered to be healthy, with no specific illnesses or weakened immune systems. The median age was about three years, ranging from less than two years to more than five years.

Vomiting and diarrhea were the most common symptoms in patients before admission, with some even experiencing upper respiratory symptoms. At the time of admission, most of the liver was enlarged, accompanied by jaundice and yellowing of the eyes.

All patients received negative test results for hepatitis A, B, and C, and pediatric hepatitis and many other causes of infection were ruled out. But adenovirus was detected in all patients.

CDC Health Advisory issued. Last week, he alerted healthcare providers and public health officials to the investigation and suggested that providers consider testing for adenovirus in children with hepatitis when the cause is not known, he added. That whole blood test – not just blood plasma – can be more sensitive. .

Of the nine patients in Alabama, six received positive test results for the Epstein-Barr virus, which was determined to be from a previous infection. Other viruses found include enterovirus / rhinovirus, metanepivirus, respiratory syncytial virus, and human corona virus OC43.

No patient had a documented history of previous CoVID-19 infection.

Three patients had severe liver failure, two of whom underwent liver transplantation. The CDC reports that all patients have recovered, including transplant recipients.

The CDC issues health advisory on acute hepatitis in children.

Hepatitis is an inflammation of the liver, an important organ that processes nutrients, filters the blood and helps fight infection. When the liver becomes swollen or damaged, its function can be affected.

Often, hepatitis is caused by a virus, and adenovirus is a common type of virus that spreads from person to person and can cause mild to severe illness. But the virus is rarely reported as a cause of acute hepatitis in healthy people.

According to the CDC, adenovirus is recognized as a cause of hepatitis in immunocompromised children, but it can be an “unrecognized contributor to liver injury in healthy children.” It mainly spreads from stool to mouth.

There is no vaccine for adenoviruses in children. According to Dr. Ashleesha Koshkak, spokeswoman for the American Academy of Pediatrics, adenoviruses stay on the surface and alcohol-based hand sanitizers do not work well against them.

“It’s best to wash your hands thoroughly with soap and water,” Koshkak said. “Stay away from anyone who is sick with coughing and sneezing, and teach your children to put cough or sneeze in their sleeve.”

CNN’s Jacqueline Howard, Brenda Goodman, Michael Needleman, John Bonifield and Jane Christensen contributed to this report.



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